Potassium channel blocking 1,2-bis(aryl)ethane-1,2-diamines active as antiarrhythmic agents.

Kajanus, Johan; Antonsson, Thomas; Carlsson, Leif; Jurva, Ulrik; Pettersen, Anna; Sundell, Johan; Inghardt, Tord

Kajanus, Johan; Antonsson, Thomas; Carlsson, Leif; Jurva, Ulrik; Pettersen, Anna; Sundell, Johan; Inghardt, Tord.

Affiliation

Kajanus J; Cardiovascular, Renal and Metabolism, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden. Electronic address: johan.kajanus@astrazeneca.com.
Antonsson T; Cardiovascular, Renal and Metabolism, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.
Carlsson L; Cardiovascular, Renal and Metabolism, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.
Jurva U; Cardiovascular, Renal and Metabolism, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.
Pettersen A; Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.
Sundell J; Cardiovascular, Renal and Metabolism, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.
Inghardt T; Cardiovascular, Renal and Metabolism, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden. Electronic address: tord.inghardt@astrazeneca.com.

Bioorg Med Chem Lett ; 29(10): 1241-1245, 2019 05 15.

Article de En | MEDLINE | ID: mdl-30879840

Sujet(s)
Mots clés

1,2-bis(aryl)ethane-1,2-diamines; Antiarrhythmic agents; Atrial fibrillation; IKur; Kv1.5; Potassium channel blocker

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Fibrillation auriculaire / Inhibiteurs des canaux potassiques / Éthylènediamines / Antiarythmiques Limites: Animals / Humans Langue: En Journal: Bioorg Med Chem Lett Sujet du journal: BIOQUIMICA / QUIMICA Année: 2019 Type de document: Article

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