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Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies.
Raman, Swetha; Beilschmidt, Melissa; To, Minh; Lin, Kevin; Lui, Francine; Jmeian, Yazen; Ng, Mark; Fernandez, Minerva; Fu, Ying; Mascall, Keith; Duque, Alejandro; Wang, Xiaowei; Pan, Guohua; Angers, Stephane; Moffat, Jason; Sidhu, Sachdev S; Magram, Jeanne; Sinclair, Angus M; Fransson, Johan; Julien, Jean-Philippe.
Affiliation
  • Raman S; Program in Molecular Medicine, Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada.
  • Beilschmidt M; Oncology Group, Northern Biologics, Toronto, ON M5G 1L7, Canada.
  • To M; Oncology Group, Northern Biologics, Toronto, ON M5G 1L7, Canada.
  • Lin K; Oncology Group, Northern Biologics, Toronto, ON M5G 1L7, Canada.
  • Lui F; Oncology Group, Northern Biologics, Toronto, ON M5G 1L7, Canada.
  • Jmeian Y; Oncology Group, Northern Biologics, Toronto, ON M5G 1L7, Canada.
  • Ng M; Oncology Group, Northern Biologics, Toronto, ON M5G 1L7, Canada.
  • Fernandez M; Oncology Group, Northern Biologics, Toronto, ON M5G 1L7, Canada.
  • Fu Y; Oncology Group, Northern Biologics, Toronto, ON M5G 1L7, Canada.
  • Mascall K; Oncology Group, Northern Biologics, Toronto, ON M5G 1L7, Canada.
  • Duque A; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada.
  • Wang X; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E2, Canada.
  • Pan G; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E2, Canada.
  • Angers S; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E2, Canada.
  • Moffat J; Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada.
  • Sidhu SS; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.
  • Magram J; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E2, Canada.
  • Sinclair AM; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
  • Fransson J; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E2, Canada.
  • Julien JP; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
Proc Natl Acad Sci U S A ; 116(14): 6812-6817, 2019 04 02.
Article de En | MEDLINE | ID: mdl-30894493
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Tumeurs du pancréas / Ingénierie des protéines / Récepteurs Frizzled / Antinéoplasiques immunologiques / Spécificité des anticorps Limites: Animals / Female / Humans Langue: En Journal: Proc Natl Acad Sci U S A Année: 2019 Type de document: Article Pays d'affiliation: Canada Pays de publication: États-Unis d'Amérique
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Tumeurs du pancréas / Ingénierie des protéines / Récepteurs Frizzled / Antinéoplasiques immunologiques / Spécificité des anticorps Limites: Animals / Female / Humans Langue: En Journal: Proc Natl Acad Sci U S A Année: 2019 Type de document: Article Pays d'affiliation: Canada Pays de publication: États-Unis d'Amérique