Association between androgen receptor gene polymorphisms and testicular germ cell tumor: A systematic review and meta-analysis.
J Cancer Res Ther
; 15(Supplement): S60-S68, 2019 Mar.
Article
de En
| MEDLINE
| ID: mdl-30900623
ABSTRACT
OBJECTIVE:
To estimate association between androgen receptor (AR) gene polymorphisms and testicular germ cell tumor (TGCT) susceptibility. MATERIALS ANDMETHODS:
Systematic search of studies on the association between AR gene polymorphisms and TGCT susceptibility was conducted. Odds ratios and 95% confidence intervals were used to pool effect size.RESULTS:
For CAG repeat, no evidence was found for association between (>25 vs. ≤25), (>25 vs. 21-25), (<21 vs. 21-25), (others vs. 21-25), (>23 vs. ≤23), (<21 vs. ≥21), (<21 vs. ≥21)'s some subgroups and TGCT susceptibility, which showed stability. In (>24 vs. ≤24), (>24 vs. 21-24), (<21 vs. 21-24), and (others vs. 21-24) and almost all of their subgroups, increased TGCT risk was found without sensitivity analysis. For GGN, no statistical change of TGCT risk was found in (<23 vs. ≥23), (<23 vs. 23), which showed stability. For single nucleotide polymorphism (SNP) rs6152 G > A, rs1204038 G > A and rs2361634 A > G, no statistical change was found without sensitivity analysis.CONCLUSIONS:
GGN repeat number <23 may not be associated with TGCTs susceptibility. However, there was insufficient data to fully confirm association in GGN repeat number >23, CAG repeat number, SNP rs6152, rs1204038, and rs2361634.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tumeurs du testicule
/
Récepteurs aux androgènes
/
Tumeurs embryonnaires et germinales
/
Répétitions de trinucléotides
/
Prédisposition génétique à une maladie
Type d'étude:
Risk_factors_studies
/
Systematic_reviews
Limites:
Humans
/
Male
Langue:
En
Journal:
J Cancer Res Ther
Sujet du journal:
NEOPLASIAS
/
TERAPEUTICA
Année:
2019
Type de document:
Article
Pays d'affiliation:
Chine