Distinct mutation spectrum, clinical outcome and therapeutic responses of typical complex/monosomy karyotype acute myeloid leukemia carrying TP53 mutations.

Leung, Garret M K; Zhang, Chunxiao; Ng, Nelson K L; Yang, Ning; Lam, Stephen S Y; Au, Chun H; Chan, Tsun L; Ma, Edmond S K; Tsui, Sze P; Ip, Ho W; So, Jason C C; Ng, Margaret H L; Cheng, Kelvin C K; Wong, Kit F; Siu, Lisa L P; Yip, Sze F; Lin, Shek Y; Lau, June S M; Luk, Tsan H; Lee, Harold K K; Lau, Chi K; Kho, Bonnie; Kwong, Yok L; Leung, Anskar Y H

Leung, Garret M K; Zhang, Chunxiao; Ng, Nelson K L; Yang, Ning; Lam, Stephen S Y; Au, Chun H; Chan, Tsun L; Ma, Edmond S K; Tsui, Sze P; Ip, Ho W; So, Jason C C; Ng, Margaret H L; Cheng, Kelvin C K; Wong, Kit F; Siu, Lisa L P; Yip, Sze F; Lin, Shek Y; Lau, June S M; Luk, Tsan H; Lee, Harold K K; Lau, Chi K; Kho, Bonnie; Kwong, Yok L; Leung, Anskar Y H.

Affiliation

Leung GMK; Division of Haematology, Department of Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China.
Zhang C; Division of Haematology, Department of Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China.
Ng NKL; Division of Haematology, Department of Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China.
Yang N; Division of Haematology, Department of Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China.
Lam SSY; Division of Haematology, Department of Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China.
Au CH; Department of Pathology, Hong Kong Sanatorium and Hospital, Hong Kong, China.
Chan TL; Department of Pathology, Hong Kong Sanatorium and Hospital, Hong Kong, China.
Ma ESK; Department of Pathology, Hong Kong Sanatorium and Hospital, Hong Kong, China.
Tsui SP; Division of Haematology, Department of Pathology, Queen Mary Hospital, Hong Kong, China.
Ip HW; Division of Haematology, Department of Pathology, Queen Mary Hospital, Hong Kong, China.
So JCC; Division of Haematology, Department of Pathology, Queen Mary Hospital, Hong Kong, China.
Ng MHL; Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, China.
Cheng KCK; Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, China.
Wong KF; Department of Pathology, Queen Elizabeth Hospital, Hong Kong, China.
Siu LLP; Department of Pathology, Queen Elizabeth Hospital, Hong Kong, China.
Yip SF; Department of Medicine, Tuen Mun Hospital, Hong Kong, China.
Lin SY; Department of Medicine and Geriatrics, United Christian Hospital, Hong Kong, China.
Lau JSM; Department of Medicine, Queen Elizabeth Hospital, Hong Kong, China.
Luk TH; Department of Medicine, Queen Elizabeth Hospital, Hong Kong, China.
Lee HKK; Department of Medicine, Princess Margaret Hospital, Hong Kong, China.
Lau CK; Department of Medicine, Tseung Kwan O Hospital, Hong Kong, China.
Kho B; Department of Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China.
Kwong YL; Division of Haematology, Department of Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China.
Leung AYH; Division of Haematology, Department of Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China.

Am J Hematol ; 94(6): 650-657, 2019 06.

Article de En | MEDLINE | ID: mdl-30900772

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Leucémie aigüe myéloïde / Protéine p53 suppresseur de tumeur / Chromosomes humains / Résistance aux médicaments antinéoplasiques / Caryotype anormal / Monosomie / Antinéoplasiques Limites: Adolescent / Adult / Female / Humans / Male / Middle aged Langue: En Journal: Am J Hematol Année: 2019 Type de document: Article Pays d'affiliation: Chine

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