Solubility-pH profile of desipramine hydrochloride in saline phosphate buffer: Enhanced solubility due to drug-buffer aggregates.

Markovic, Olivera S; Pesic, Milos P; Shah, Ankita V; Serajuddin, Abu T M; Verbic, Tatjana Z; Avdeef, Alex

Markovic, Olivera S; Pesic, Milos P; Shah, Ankita V; Serajuddin, Abu T M; Verbic, Tatjana Z; Avdeef, Alex.

Affiliation

Markovic OS; Department of Chemistry, IChTM, University of Belgrade, Njegoseva 12, 11000 Belgrade, Serbia. Electronic address: olivera.markovic@ihtm.bg.ac.rs.
Pesic MP; University of Belgrade, Faculty of Chemistry, Studentski trg 12-16, 11000 Belgrade, Serbia. Electronic address: mpesic@chem.bg.ac.rs.
Shah AV; St. John's University, College of Pharmacy and Health Sciences, 8000 Utopia Parkway, Queens, NY 11439, USA. Electronic address: Ankita.Shah@freund-vector.com.
Serajuddin ATM; St. John's University, College of Pharmacy and Health Sciences, 8000 Utopia Parkway, Queens, NY 11439, USA. Electronic address: serajuda@stjohns.edu.
Verbic TZ; University of Belgrade, Faculty of Chemistry, Studentski trg 12-16, 11000 Belgrade, Serbia. Electronic address: tatjanad@chem.bg.ac.rs.
Avdeef A; in-ADME Research, 1732 First Avenue #102, New York, NY 10128, USA. Electronic address: alex@in-ADME.com.

Eur J Pharm Sci ; 133: 264-274, 2019 May 15.

Article de En | MEDLINE | ID: mdl-30914359

Sujet(s)
Mots clés

Buffer effect; Desipramine-phosphate complexes; Solubility product; pDISOL-X; pH effect; pH-Ramp Shake-Flask method

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Phosphates / Chlorures / Désipramine / Antidépresseurs tricycliques Langue: En Journal: Eur J Pharm Sci Sujet du journal: FARMACIA / FARMACOLOGIA / QUIMICA Année: 2019 Type de document: Article

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