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Chemotherapy and Beyond: Infections in the Era of Old and New Treatments for Hematologic Malignancies.
Atkins, Sarah; He, Fiona.
Affiliation
  • Atkins S; Department of Internal Medicine, University of Minnesota, 420 Delaware Street Southeast, MMC 284, Minneapolis, MN 55455, USA.
  • He F; Division of Hematology, Oncology, and Transplantation, University of Minnesota, 420 Delaware Street Southeast, MMC 480, Minneapolis, MN 55455, USA. Electronic address: fionahe@umn.edu.
Infect Dis Clin North Am ; 33(2): 289-309, 2019 06.
Article de En | MEDLINE | ID: mdl-30935703
ABSTRACT
Treatment options for hematologic malignancies have been rapidly expanding in the past decade, resulting in better survival outcomes for many patients. Infection is an important cause of morbidity and mortality in this patient population. Cytotoxic chemotherapy has well-studied infectious risks related to the degree and duration of myelosuppression. Targeted therapies and immunotherapies have less clearly predictable infectious risk and diverse effects on immune function. This review discusses contemporary management of hematologic malignancies, followed by special discussion of novel agents, including signaling/small molecule inhibitors, monoclonal antibodies, immunomodulators, and immunotherapies, for treatment of hematologic malignancies with focus on infectious risk.
Sujet(s)
Mots clés

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Maladies transmissibles / Tumeurs hématologiques / Traitement médicamenteux / Anticorps monoclonaux Type d'étude: Prognostic_studies Limites: Humans Langue: En Journal: Infect Dis Clin North Am Sujet du journal: DOENCAS TRANSMISSIVEIS Année: 2019 Type de document: Article Pays d'affiliation: États-Unis d'Amérique

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Maladies transmissibles / Tumeurs hématologiques / Traitement médicamenteux / Anticorps monoclonaux Type d'étude: Prognostic_studies Limites: Humans Langue: En Journal: Infect Dis Clin North Am Sujet du journal: DOENCAS TRANSMISSIVEIS Année: 2019 Type de document: Article Pays d'affiliation: États-Unis d'Amérique