Chemotherapy and Beyond: Infections in the Era of Old and New Treatments for Hematologic Malignancies.
Infect Dis Clin North Am
; 33(2): 289-309, 2019 06.
Article
de En
| MEDLINE
| ID: mdl-30935703
ABSTRACT
Treatment options for hematologic malignancies have been rapidly expanding in the past decade, resulting in better survival outcomes for many patients. Infection is an important cause of morbidity and mortality in this patient population. Cytotoxic chemotherapy has well-studied infectious risks related to the degree and duration of myelosuppression. Targeted therapies and immunotherapies have less clearly predictable infectious risk and diverse effects on immune function. This review discusses contemporary management of hematologic malignancies, followed by special discussion of novel agents, including signaling/small molecule inhibitors, monoclonal antibodies, immunomodulators, and immunotherapies, for treatment of hematologic malignancies with focus on infectious risk.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Maladies transmissibles
/
Tumeurs hématologiques
/
Traitement médicamenteux
/
Anticorps monoclonaux
Type d'étude:
Prognostic_studies
Limites:
Humans
Langue:
En
Journal:
Infect Dis Clin North Am
Sujet du journal:
DOENCAS TRANSMISSIVEIS
Année:
2019
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique