Genomic signature of early T-cell response is associated with lower antibody titer threshold for sterilizing immunity.
Antiviral Res
; 166: 35-41, 2019 06.
Article
de En
| MEDLINE
| ID: mdl-30940521
ABSTRACT
Vaccination is an effective approach to reduce disease burden. High vaccination coverage blocks pathogen transmission to ensure herd immunity. However, the concept of herd immunity assumes that vaccinated individuals cannot be infected and mediate silent pathogen transmission. While the correlates of vaccine-mediated protection against disease have been examined, the correlates of sterilizing immunity that prevents infection have not been systematically defined. Here, we used full genome expression profiling to explore the molecular correlates of serological response and non-response to measles, mumps and rubella (MMR) vaccination as surrogates of infection and sterilizing immunity, respectively. We observed that the antibody titers needed to sterilize infection with the vaccine strains were higher than current WHO disease protection thresholds. In subjects with baseline antibodies below such sterilizing immunity thresholds, serological non-response to MMR vaccination was associated with gene expression profile indicative of early T-cell activation and signalling. Specifically, genes that regulate T-cell function and response were induced at day 1 post-vaccination in non-responders but not in responders. These findings suggest that rapid T-cell response prevented MMR vaccine infection to limit antigenic presentation and hence serological response. Collectively, our findings suggest an important role for T-cells in engendering sterilizing immunity.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Lymphocytes T
/
Vaccin contre la rougeole, les oreillons et la rubéole
/
Anticorps antiviraux
Type d'étude:
Risk_factors_studies
Limites:
Female
/
Humans
/
Male
Langue:
En
Journal:
Antiviral Res
Année:
2019
Type de document:
Article
Pays d'affiliation:
Singapour