Identification of Major Esterase Involved in Hydrolysis of Soft Anticholinergic (2R3'R-SGM) Designed From Glycopyrrolate in Human and Rat Tissues.

Samir, Ahmed; Ohura, Kayoko; Bodor, Nicholas; Imai, Teruko

Samir, Ahmed; Ohura, Kayoko; Bodor, Nicholas; Imai, Teruko.

Affiliation

Samir A; Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan.
Ohura K; Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan; Priority Organization for Innovation and Excellence, Kumamoto University, Kumamoto, Japan.
Bodor N; Bodor Laboratories, Miami, Florida 33137; College of Pharmacy, University of Florida, Gainesville, Florida 32611.
Imai T; Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan. Electronic address: iteruko@gpo.kumamoto-u.ac.jp.

J Pharm Sci ; 108(8): 2791-2797, 2019 08.

Article de En | MEDLINE | ID: mdl-30954525

Sujet(s)
Mots clés

drug design; enzyme(s); hydrolysis; metabolism; phase I enzyme(s); protein binding

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Antagonistes cholinergiques / Esterases / Glycopyrronium Type d'étude: Diagnostic_studies Limites: Animals / Female / Humans / Male Langue: En Journal: J Pharm Sci Année: 2019 Type de document: Article Pays d'affiliation: Japon

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