Human Salivary Amylase Gene Copy Number Impacts Oral and Gut Microbiomes.
Cell Host Microbe
; 25(4): 553-564.e7, 2019 Apr 10.
Article
de En
| MEDLINE
| ID: mdl-30974084
ABSTRACT
Host genetic variation influences microbiome composition. While studies have focused on associations between the gut microbiome and specific alleles, gene copy number (CN) also varies. We relate microbiome diversity to CN variation of the AMY1 locus, which encodes salivary amylase, facilitating starch digestion. After imputing AMY1-CN for â¼1,000 subjects, we identified taxa differentiating fecal microbiomes of high and low AMY1-CN hosts. In a month-long diet intervention study, we show that diet standardization drove gut microbiome convergence, and AMY1-CN correlated with oral and gut microbiome composition and function. The microbiomes of low-AMY1-CN subjects had enhanced capacity to break down complex carbohydrates. High-AMY1-CN subjects had higher levels of salivary Porphyromonas; their gut microbiota had increased abundance of resistant starch-degrading microbes, produced higher levels of short-chain fatty acids, and drove higher adiposity when transferred to germ-free mice. This study establishes AMY1-CN as a genetic factor associated with microbiome composition and function.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Salive
/
Dosage génique
/
Tube digestif
/
Microbiote
/
Amylases
/
Bouche
Type d'étude:
Prognostic_studies
Limites:
Animals
/
Humans
Langue:
En
Journal:
Cell Host Microbe
Sujet du journal:
MICROBIOLOGIA
Année:
2019
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique