Suppression of pyrimidine biosynthesis by targeting DHODH enzyme robustly inhibits rotavirus replication.

Chen, Sunrui; Ding, Shihao; Yin, Yuebang; Xu, Lei; Li, Pengfei; Peppelenbosch, Maikel P; Pan, Qiuwei; Wang, Wenshi

Chen, Sunrui; Ding, Shihao; Yin, Yuebang; Xu, Lei; Li, Pengfei; Peppelenbosch, Maikel P; Pan, Qiuwei; Wang, Wenshi.

Affiliation

Chen S; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.
Ding S; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.
Yin Y; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.
Xu L; College of Life Sciences, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Li P; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.
Peppelenbosch MP; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.
Pan Q; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.
Wang W; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands. Electronic address: w.wang.2@erasmusmc.nl.

Antiviral Res ; 167: 35-44, 2019 07.

Article de En | MEDLINE | ID: mdl-30974126

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Nucléosides pyrimidiques / Rotavirus / Oxidoreductases acting on CH-CH group donors / Antienzymes Limites: Humans Langue: En Journal: Antiviral Res Année: 2019 Type de document: Article Pays d'affiliation: Pays-Bas Pays de publication: Pays-Bas

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