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The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight.
Garrett-Bakelman, Francine E; Darshi, Manjula; Green, Stefan J; Gur, Ruben C; Lin, Ling; Macias, Brandon R; McKenna, Miles J; Meydan, Cem; Mishra, Tejaswini; Nasrini, Jad; Piening, Brian D; Rizzardi, Lindsay F; Sharma, Kumar; Siamwala, Jamila H; Taylor, Lynn; Vitaterna, Martha Hotz; Afkarian, Maryam; Afshinnekoo, Ebrahim; Ahadi, Sara; Ambati, Aditya; Arya, Maneesh; Bezdan, Daniela; Callahan, Colin M; Chen, Songjie; Choi, Augustine M K; Chlipala, George E; Contrepois, Kévin; Covington, Marisa; Crucian, Brian E; De Vivo, Immaculata; Dinges, David F; Ebert, Douglas J; Feinberg, Jason I; Gandara, Jorge A; George, Kerry A; Goutsias, John; Grills, George S; Hargens, Alan R; Heer, Martina; Hillary, Ryan P; Hoofnagle, Andrew N; Hook, Vivian Y H; Jenkinson, Garrett; Jiang, Peng; Keshavarzian, Ali; Laurie, Steven S; Lee-McMullen, Brittany; Lumpkins, Sarah B; MacKay, Matthew; Maienschein-Cline, Mark G.
Affiliation
  • Garrett-Bakelman FE; Weill Cornell Medicine, New York, NY, USA.
  • Darshi M; University of Virginia School of Medicine, Charlottesville, VA, USA.
  • Green SJ; Center for Renal Precision Medicine, University of Texas Health, San Antonio, TX, USA.
  • Gur RC; University of Illinois at Chicago, Chicago, IL, USA.
  • Lin L; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Macias BR; Stanford University School of Medicine, Palo Alto, CA, USA.
  • McKenna MJ; KBRwyle, Houston, TX, USA.
  • Meydan C; Colorado State University, Fort Collins, CO, USA.
  • Mishra T; Weill Cornell Medicine, New York, NY, USA.
  • Nasrini J; The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, New York, NY, USA.
  • Piening BD; Stanford University School of Medicine, Palo Alto, CA, USA.
  • Rizzardi LF; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Sharma K; Stanford University School of Medicine, Palo Alto, CA, USA.
  • Siamwala JH; Johns Hopkins University, Baltimore, MD, USA.
  • Taylor L; Center for Renal Precision Medicine, University of Texas Health, San Antonio, TX, USA.
  • Vitaterna MH; University of California, San Diego, La Jolla, CA, USA.
  • Afkarian M; Colorado State University, Fort Collins, CO, USA.
  • Afshinnekoo E; Northwestern University, Evanston, IL, USA.
  • Ahadi S; University of California, Davis, Davis, CA, USA.
  • Ambati A; Weill Cornell Medicine, New York, NY, USA.
  • Arya M; The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, New York, NY, USA.
  • Bezdan D; Stanford University School of Medicine, Palo Alto, CA, USA.
  • Callahan CM; Stanford University School of Medicine, Palo Alto, CA, USA.
  • Chen S; KBRwyle, Houston, TX, USA.
  • Choi AMK; Weill Cornell Medicine, New York, NY, USA.
  • Chlipala GE; The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, New York, NY, USA.
  • Contrepois K; Johns Hopkins University, Baltimore, MD, USA.
  • Covington M; Stanford University School of Medicine, Palo Alto, CA, USA.
  • Crucian BE; Weill Cornell Medicine, New York, NY, USA.
  • De Vivo I; University of Illinois at Chicago, Chicago, IL, USA.
  • Dinges DF; Stanford University School of Medicine, Palo Alto, CA, USA.
  • Ebert DJ; National Aeronautics and Space Administration (NASA), Houston, TX, USA.
  • Feinberg JI; National Aeronautics and Space Administration (NASA), Houston, TX, USA.
  • Gandara JA; Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • George KA; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Goutsias J; KBRwyle, Houston, TX, USA.
  • Grills GS; Johns Hopkins University, Baltimore, MD, USA.
  • Hargens AR; Weill Cornell Medicine, New York, NY, USA.
  • Heer M; KBRwyle, Houston, TX, USA.
  • Hillary RP; Johns Hopkins University, Baltimore, MD, USA.
  • Hoofnagle AN; Weill Cornell Medicine, New York, NY, USA.
  • Hook VYH; University of California, San Diego, La Jolla, CA, USA.
  • Jenkinson G; University of Bonn, Bonn, Germany.
  • Jiang P; Stanford University School of Medicine, Palo Alto, CA, USA.
  • Keshavarzian A; University of Washington, Seattle, WA, USA.
  • Laurie SS; University of California, San Diego, La Jolla, CA, USA.
  • Lee-McMullen B; Johns Hopkins University, Baltimore, MD, USA.
  • Lumpkins SB; Northwestern University, Evanston, IL, USA.
  • MacKay M; Rush University Medical Center, Chicago, IL, USA.
  • Maienschein-Cline MG; KBRwyle, Houston, TX, USA.
Science ; 364(6436)2019 04 12.
Article de En | MEDLINE | ID: mdl-30975860
ABSTRACT
To understand the health impact of long-duration spaceflight, one identical twin astronaut was monitored before, during, and after a 1-year mission onboard the International Space Station; his twin served as a genetically matched ground control. Longitudinal assessments identified spaceflight-specific changes, including decreased body mass, telomere elongation, genome instability, carotid artery distension and increased intima-media thickness, altered ocular structure, transcriptional and metabolic changes, DNA methylation changes in immune and oxidative stress-related pathways, gastrointestinal microbiota alterations, and some cognitive decline postflight. Although average telomere length, global gene expression, and microbiome changes returned to near preflight levels within 6 months after return to Earth, increased numbers of short telomeres were observed and expression of some genes was still disrupted. These multiomic, molecular, physiological, and behavioral datasets provide a valuable roadmap of the putative health risks for future human spaceflight.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Vol spatial / Adaptation physiologique / Astronaute Type d'étude: Prognostic_studies Limites: Humans / Male Pays/Région comme sujet: America do norte Langue: En Journal: Science Année: 2019 Type de document: Article Pays d'affiliation: États-Unis d'Amérique
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Vol spatial / Adaptation physiologique / Astronaute Type d'étude: Prognostic_studies Limites: Humans / Male Pays/Région comme sujet: America do norte Langue: En Journal: Science Année: 2019 Type de document: Article Pays d'affiliation: États-Unis d'Amérique