CXCL12-CXCR4 pathway activates brown adipocytes and induces insulin resistance in CXCR4-deficient mice under high-fat diet.

Kurita, Kenichi; Ishikawa, Ko; Takeda, Kenji; Fujimoto, Masanori; Ono, Hiraku; Kumagai, Jin; Inoue, Hiromi; Yokoh, Hidetaka; Yokote, Koutaro

Kurita, Kenichi; Ishikawa, Ko; Takeda, Kenji; Fujimoto, Masanori; Ono, Hiraku; Kumagai, Jin; Inoue, Hiromi; Yokoh, Hidetaka; Yokote, Koutaro.

Affiliation

Kurita K; Department of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan.
Ishikawa K; Division of Diabetes, Metabolism and Endocrinology, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan.
Takeda K; Department of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan. ishikawako1225@gmail.com.
Fujimoto M; Division of Diabetes, Metabolism and Endocrinology, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan. ishikawako1225@gmail.com.
Ono H; Department of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan.
Kumagai J; Division of Diabetes, Metabolism and Endocrinology, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan.
Inoue H; Department of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan.
Yokoh H; Division of Diabetes, Metabolism and Endocrinology, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan.
Yokote K; Department of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan.

Sci Rep ; 9(1): 6165, 2019 04 16.

Article de En | MEDLINE | ID: mdl-30992469

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Insulinorésistance / Transduction du signal / Récepteurs CXCR4 / Adipocytes bruns / Chimiokine CXCL12 Limites: Animals Langue: En Journal: Sci Rep Année: 2019 Type de document: Article Pays d'affiliation: Japon Pays de publication: Royaume-Uni

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