Non-genotoxic MDM2 inhibition selectively induces a pro-apoptotic p53 gene signature in chronic lymphocytic leukemia cells.

Ciardullo, Carmela; Aptullahoglu, Erhan; Woodhouse, Laura; Lin, Wei-Yu; Wallis, Jonathan P; Marr, Helen; Marshall, Scott; Bown, Nick; Willmore, Elaine; Lunec, John

Ciardullo, Carmela; Aptullahoglu, Erhan; Woodhouse, Laura; Lin, Wei-Yu; Wallis, Jonathan P; Marr, Helen; Marshall, Scott; Bown, Nick; Willmore, Elaine; Lunec, John.

Affiliation

Ciardullo C; Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne.
Aptullahoglu E; Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne.
Woodhouse L; Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne.
Lin WY; Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne.
Wallis JP; Department of Haematology, Freeman Hospital, The Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne.
Marr H; Department of Haematology, Freeman Hospital, The Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne.
Marshall S; Department of Haematology, City Hospitals Sunderland NHS Trust, Sunderland.
Bown N; Northern Genetics Service, Institute of Genetic Medicine, Newcastle upon Tyne, UK.
Willmore E; Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne.
Lunec J; Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne john.lunec@ncl.ac.uk.

Haematologica ; 104(12): 2429-2442, 2019 12.

Article de En | MEDLINE | ID: mdl-31004033

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pyrrolidines / Leucémie myéloïde chronique BCR-ABL positive / Marqueurs biologiques tumoraux / Régulation de l'expression des gènes tumoraux / Protéine p53 suppresseur de tumeur / Apoptose / Protéines proto-oncogènes c-mdm2 / Para-Aminobenzoates Limites: Humans Langue: En Journal: Haematologica Année: 2019 Type de document: Article

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