Evaluation and Management of Congenital Chagas Disease in the United States.
J Pediatric Infect Dis Soc
; 8(5): 461-469, 2019 Nov 06.
Article
de En
| MEDLINE
| ID: mdl-31016324
ABSTRACT
Chagas disease is underappreciated as a health concern in the United States. Approximately 40 000 women of childbearing age living in the United States have chronic Chagas disease. Most of them are unaware that they have an infection that is transmissible to their offspring. The estimated US maternal-to-infant transmission rate of Trypanosoma cruzi is 1% to 5%. Ten percent to 40% of neonates with congenital T cruzi infection have clinical signs consistent with a congenital infection but no findings are unique to Chagas disease. If left untreated, 20% to 40% of infants with Chagas disease will later develop potentially fatal cardiac manifestations. Molecular testing can confirm the diagnosis in neonates. Treatment is well tolerated in infancy and usually results in cure. Screening of at-risk women during pregnancy can identify maternal infection and allow early assessment and treatment for congenital T cruzi infection.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Maladie de Chagas
/
Complications parasitaires de la grossesse
/
Transmission verticale de maladie infectieuse
Type d'étude:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites:
Female
/
Humans
/
Infant
/
Newborn
/
Pregnancy
Pays/Région comme sujet:
America do norte
Langue:
En
Journal:
J Pediatric Infect Dis Soc
Année:
2019
Type de document:
Article