Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects.

Klotz, Luisa; Eschborn, Melanie; Lindner, Maren; Liebmann, Marie; Herold, Martin; Janoschka, Claudia; Torres Garrido, Belén; Schulte-Mecklenbeck, Andreas; Gross, Catharina C; Breuer, Johanna; Hundehege, Petra; Posevitz, Vilmos; Pignolet, Béatrice; Nebel, Giulia; Glander, Shirin; Freise, Nicole; Austermann, Judith; Wirth, Timo; Campbell, Graham R; Schneider-Hohendorf, Tilman; Eveslage, Maria; Brassat, David; Schwab, Nicholas; Loser, Karin; Roth, Johannes; Busch, Karin B; Stoll, Monika; Mahad, Don J; Meuth, Sven G; Turner, Timothy; Bar-Or, Amit; Wiendl, Heinz

Klotz, Luisa; Eschborn, Melanie; Lindner, Maren; Liebmann, Marie; Herold, Martin; Janoschka, Claudia; Torres Garrido, Belén; Schulte-Mecklenbeck, Andreas; Gross, Catharina C; Breuer, Johanna; Hundehege, Petra; Posevitz, Vilmos; Pignolet, Béatrice; Nebel, Giulia; Glander, Shirin; Freise, Nicole; Austermann, Judith; Wirth, Timo; Campbell, Graham R; Schneider-Hohendorf, Tilman; Eveslage, Maria; Brassat, David; Schwab, Nicholas; Loser, Karin; Roth, Johannes; Busch, Karin B; Stoll, Monika; Mahad, Don J; Meuth, Sven G; Turner, Timothy; Bar-Or, Amit; Wiendl, Heinz.

Affiliation

Klotz L; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany. luisa.klotz@ukmuenster.de.
Eschborn M; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.
Lindner M; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.
Liebmann M; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.
Herold M; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.
Janoschka C; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.
Torres Garrido B; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.
Schulte-Mecklenbeck A; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.
Gross CC; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.
Breuer J; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.
Hundehege P; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.
Posevitz V; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.
Pignolet B; CRC-SEP, Neurosciences Department, Toulouse University Hospital and INSERM U1043 - CNRS UMR 5282, Centre de Physiopathologie Toulouse-Purpan, Université Toulouse III, 31300 Toulouse, France.
Nebel G; University of Münster, Institute of Molecular Cell Biology, 48149 Münster, Germany.
Glander S; University of Münster, Department of Genetic Epidemiology, 48149 Münster, Germany.
Freise N; University of Münster, Department of Immunology, 48149 Münster, Germany.
Austermann J; University of Münster, Department of Immunology, 48149 Münster, Germany.
Wirth T; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.
Campbell GR; University of Edinburgh, Centre for Clinical Brain Sciences, EH8 9YL Edinburgh, UK.
Schneider-Hohendorf T; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.
Eveslage M; University of Münster, Institute of Biostatistics and Clinical Research, 48149 Münster, Germany.
Brassat D; CRC-SEP, Neurosciences Department, Toulouse University Hospital and INSERM U1043 - CNRS UMR 5282, Centre de Physiopathologie Toulouse-Purpan, Université Toulouse III, 31300 Toulouse, France.
Schwab N; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.
Loser K; University Hospital Münster, Department of Dermatology, 48149 Münster, Germany.
Roth J; University of Münster, Department of Immunology, 48149 Münster, Germany.
Busch KB; University of Münster, Institute of Molecular Cell Biology, 48149 Münster, Germany.
Stoll M; University of Münster, Department of Genetic Epidemiology, 48149 Münster, Germany.
Mahad DJ; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, 6229 ER Maastricht, Netherlands.
Meuth SG; University of Edinburgh, Centre for Clinical Brain Sciences, EH8 9YL Edinburgh, UK.
Turner T; University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.
Bar-Or A; Sanofi Genzyme, Cambridge, MA 02142, USA.
Wiendl H; Center for Neuroinflammation and Experimental Therapeutics and Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Sci Transl Med ; 11(490)2019 05 01.

Article de En | MEDLINE | ID: mdl-31043571

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Toluidines / Crotonates / Lymphocytes T / Mitochondries / Sclérose en plaques Type d'étude: Clinical_trials Limites: Animals / Humans Langue: En Journal: Sci Transl Med Sujet du journal: CIENCIA / MEDICINA Année: 2019 Type de document: Article Pays d'affiliation: Allemagne Pays de publication: États-Unis d'Amérique

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