Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis.

Widjaja, Anissa A; Singh, Brijesh K; Adami, Eleonora; Viswanathan, Sivakumar; Dong, Jinrui; D'Agostino, Giuseppe A; Ng, Benjamin; Lim, Wei Wen; Tan, Jessie; Paleja, Bhairav S; Tripathi, Madhulika; Lim, Sze Yun; Shekeran, Shamini Guna; Chothani, Sonia P; Rabes, Anne; Sombetzki, Martina; Bruinstroop, Eveline; Min, Lio Pei; Sinha, Rohit A; Albani, Salvatore; Yen, Paul M; Schafer, Sebastian; Cook, Stuart A

Widjaja, Anissa A; Singh, Brijesh K; Adami, Eleonora; Viswanathan, Sivakumar; Dong, Jinrui; D'Agostino, Giuseppe A; Ng, Benjamin; Lim, Wei Wen; Tan, Jessie; Paleja, Bhairav S; Tripathi, Madhulika; Lim, Sze Yun; Shekeran, Shamini Guna; Chothani, Sonia P; Rabes, Anne; Sombetzki, Martina; Bruinstroop, Eveline; Min, Lio Pei; Sinha, Rohit A; Albani, Salvatore; Yen, Paul M; Schafer, Sebastian; Cook, Stuart A.

Affiliation

Widjaja AA; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore.
Singh BK; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore.
Adami E; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore.
Viswanathan S; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore.
Dong J; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore.
D'Agostino GA; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore.
Ng B; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore.
Lim WW; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore.
Tan J; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore.
Paleja BS; Translational Immunology Institute, SingHealth/Duke-NUS Academic Medical Centre, Singapore.
Tripathi M; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore.
Lim SY; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore.
Shekeran SG; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore.
Chothani SP; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore.
Rabes A; Department of Tropical Medicine and Infectious Diseases, University Medical Center, Rostock, Germany.
Sombetzki M; Department of Tropical Medicine and Infectious Diseases, University Medical Center, Rostock, Germany.
Bruinstroop E; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore.
Min LP; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore.
Sinha RA; Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Albani S; Translational Immunology Institute, SingHealth/Duke-NUS Academic Medical Centre, Singapore.
Yen PM; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore.
Schafer S; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore.
Cook SA; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore; National Heart and Lung Institute, Imperial College London, London, UK; MRC-London Institute of Me

Gastroenterology ; 157(3): 777-792.e14, 2019 09.

Article de En | MEDLINE | ID: mdl-31078624

Sujet(s)
Mots clés

Acta2; Alanine Aminotransferase; Collagen; Fatty Liver

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Interleukine-11 / Sous-unité alpha du récepteur à l'interleukine-11 / Anticorps neutralisants / Stéatose hépatique non alcoolique / Hépatite / Foie / Cirrhose expérimentale Type d'étude: Prognostic_studies Langue: En Journal: Gastroenterology Année: 2019 Type de document: Article Pays d'affiliation: Singapour Pays de publication: États-Unis d'Amérique

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