Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors.

Bryan, Marian C; Drobnick, Joy; Gobbi, Alberto; Kolesnikov, Aleksandr; Chen, Yongsheng; Rajapaksa, Naomi; Ndubaku, Chudi; Feng, Jianwen; Chang, Willy; Francis, Ross; Yu, Christine; Choo, Edna F; DeMent, Kevin; Ran, Yingqing; An, Le; Emson, Claire; Huang, Zhiyu; Sujatha-Bhaskar, Swathi; Brightbill, Hans; DiPasquale, Antonio; Maher, Jonathan; Wai, John; McKenzie, Brent S; Lupardus, Patrick J; Zarrin, Ali A; Kiefer, James R

Bryan, Marian C; Drobnick, Joy; Gobbi, Alberto; Kolesnikov, Aleksandr; Chen, Yongsheng; Rajapaksa, Naomi; Ndubaku, Chudi; Feng, Jianwen; Chang, Willy; Francis, Ross; Yu, Christine; Choo, Edna F; DeMent, Kevin; Ran, Yingqing; An, Le; Emson, Claire; Huang, Zhiyu; Sujatha-Bhaskar, Swathi; Brightbill, Hans; DiPasquale, Antonio; Maher, Jonathan; Wai, John; McKenzie, Brent S; Lupardus, Patrick J; Zarrin, Ali A; Kiefer, James R.

Affiliation

Bryan MC; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
Drobnick J; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
Gobbi A; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
Kolesnikov A; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
Chen Y; WuXi Apptec , 288 Fute Zhong Road, Waigaoqiao Free Trade Zone , Shanghai 200131 , P. R. China.
Rajapaksa N; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
Ndubaku C; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
Feng J; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
Chang W; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
Francis R; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
Yu C; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
Choo EF; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
DeMent K; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
Ran Y; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
An L; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
Emson C; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
Huang Z; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
Sujatha-Bhaskar S; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
Brightbill H; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
DiPasquale A; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
Maher J; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
Wai J; WuXi Apptec , 288 Fute Zhong Road, Waigaoqiao Free Trade Zone , Shanghai 200131 , P. R. China.
McKenzie BS; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
Lupardus PJ; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
Zarrin AA; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.
Kiefer JR; Genentech, Inc. , One DNA Way , South San Francisco , California 94080 , United States.

J Med Chem ; 62(13): 6223-6240, 2019 07 11.

Article de En | MEDLINE | ID: mdl-31082230

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pyrazoles / Pyrimidines / Inhibiteurs de protéines kinases / Interleukin-1 Receptor-Associated Kinases Limites: Animals / Female / Humans Langue: En Journal: J Med Chem Sujet du journal: QUIMICA Année: 2019 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: États-Unis d'Amérique

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