Roadmap to functional cure of chronic hepatitis B: An expert consensus.
J Viral Hepat
; 26(10): 1146-1155, 2019 10.
Article
de En
| MEDLINE
| ID: mdl-31087479
Hepatitis B virus (HBV) infection continues to be a major public health issue worldwide. HBsAg loss is associated with functional remission and improved long-term outcome, and is considered to be a 'functional cure' (also referred to as clinical or immunologic cure) for chronic hepatitis B. This ideal goal of therapy can be achieved using optimized combination regimens with direct-acting antivirals [eg nucleos(t)ide analogues (NAs)] and immunomodulators [eg pegylated interferon alpha2a (Peg-IFN)] in selected patients with chronic hepatitis B. Among different combination therapies currently available, those with NA lead-in followed by Peg-IFN in virally suppressed patients has been demonstrated to be effective. This review provides an updated overview of the evidence supporting the use of combination therapies and summarizes expert consensus on the roadmap to attain functional cure for chronic hepatitis B patients.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Antiviraux
/
Hépatite B chronique
/
Association de médicaments
/
Facteurs immunologiques
Type d'étude:
Guideline
Limites:
Humans
Langue:
En
Journal:
J Viral Hepat
Sujet du journal:
GASTROENTEROLOGIA
Année:
2019
Type de document:
Article
Pays d'affiliation:
Chine
Pays de publication:
Royaume-Uni