Robust synthesis of C-terminal cysteine-containing peptide acids through a peptide hydrazide-based strategy.
Org Biomol Chem
; 17(23): 5698-5702, 2019 06 12.
Article
de En
| MEDLINE
| ID: mdl-31135013
ABSTRACT
A new robust strategy was reported for the epimerization-free synthesis of C-terminal Cys-containing peptide acids through mercaptoethanol-mediated hydrolysis of peptide thioesters prepared in situ from peptide hydrazides. This simple-to-operate and highly efficient method avoids the use of derivatization reagents for resin modification, thus providing a practical avenue for the preparation of C-terminal Cys-containing peptide acids.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Peptides
/
Acides
/
Cystéine
Langue:
En
Journal:
Org Biomol Chem
Sujet du journal:
BIOQUIMICA
/
QUIMICA
Année:
2019
Type de document:
Article