The Ca-loop in thymidylate kinase is critical for growth and contributes to pyrimidine drug sensitivity of <i>Candida albicans</i>.

Huang, Chang-Yu; Chen, Yee-Chun; Wu-Hsieh, Betty A; Fang, Jim-Min; Chang, Zee-Fen

The Ca-loop in thymidylate kinase is critical for growth and contributes to pyrimidine drug sensitivity of Candida albicans.

Huang, Chang-Yu; Chen, Yee-Chun; Wu-Hsieh, Betty A; Fang, Jim-Min; Chang, Zee-Fen.

Affiliation

Huang CY; From the Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Linong Street, Taipei 11221.
Chen YC; the Institute of Molecular Medicine, College of Medicine, National Taiwan University, Jen-Ai Road, Taipei 10051.
Wu-Hsieh BA; the National Taiwan University Hospital and College of Medicine.
Fang JM; Center of Precision Medicine, College of Medicine, National Taiwan University, Taipei 10002.
Chang ZF; the Graduate Institute of Immunology, College of Medicine, National Taiwan University, Jen-Ai Road, Taipei 10051, and.

J Biol Chem ; 294(27): 10686-10697, 2019 07 05.

Article de En | MEDLINE | ID: mdl-31152062

Sujet(s)
Mots clés

Candida albicans; DNA damage; drug resistance; nucleoside/nucleotide analogue; substrate specificity; thymidylate kinase

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pyrimidines / Candida albicans / Protéines fongiques / Nucleoside phosphate kinase Type d'étude: Diagnostic_studies / Prognostic_studies Limites: Humans Langue: En Journal: J Biol Chem Année: 2019 Type de document: Article

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