[Simultaneous determination of leucovorin and 5-methyl-tetrahydrofolate diastereoisomers in human plasma by high-performance liquid chromatography-tandem mass spectrometry coupled with ultrafiltration centrifugation-based pretreatment and its application to a pharmacokinetic study].

Xu, Chenfeng; Hui, Wenkai; Sun, Lili; Gao, Qianqian; Zou, Qiaogen

Xu, Chenfeng; Hui, Wenkai; Sun, Lili; Gao, Qianqian; Zou, Qiaogen.

Affiliation

Xu C; Nanjing Tech University, Nanjing 211800, China.
Hui W; Chia Tai Tianqing Pharmaceutical Group Co., Ltd, Lianyungang 222000, China.
Sun L; Nanjing Healthnice Medical Technology Co., Ltd, Nanjing 210009, China.
Gao Q; Nanjing Healthnice Medical Technology Co., Ltd, Nanjing 210009, China.
Zou Q; Nanjing Tech University, Nanjing 211800, China.

Se Pu ; 37(6): 581-588, 2019 Jun 08.

Article de Zh | MEDLINE | ID: mdl-31152507

Sujet(s)
Mots clés

chiral separation; high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS); leucovorin (LV); pharmacokinetics; ultrafiltration centrifugation

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Tétrahydrofolates / Leucovorine Limites: Humans Langue: Zh Journal: Se Pu Année: 2019 Type de document: Article Pays d'affiliation: Chine Pays de publication: Chine

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