Correlation of serum and synovial leptin concentrations with body condition scores in healthy and osteoarthritic dogs.
Vet Surg
; 48(5): 780-785, 2019 Jul.
Article
de En
| MEDLINE
| ID: mdl-31155740
ABSTRACT
OBJECTIVE:
To evaluate the relationship between serum and synovial fluid (SF) leptin concentrations and body condition score (BCS) in healthy and osteoarthritic dogs. STUDYDESIGN:
Controlled, prospective, clinical study. ANIMALS Nineteen healthy dogs and 29 dogs with osteoarthritis (OA) secondary to cranial cruciate ligament injury.METHODS:
Synovial fluid was obtained from the femorotibial joint under sedation (healthy dogs) or during surgery (OA dogs). Serum and SF leptin and interleukin (IL)-1ß concentrations were measured via enzyme-linked immunosorbent assay. Dogs were classified as optimal weight (BCS 4-5/9) or overweight (BCS >5/9). Radiographs were scored for OA severity by a radiologist. Owners completed the Liverpool Osteoarthritis in Dogs (LOAD) questionnaire.RESULTS:
Mean (± SD) SF leptin (4.09 ± 4 ng/mL) was lower than serum leptin (6.88 ± 5.52 ng/mL, P < .0001). Synovial fluid leptin was higher in overweight (5.28 ± 4.21) than in optimal body weight dogs (1.54 ± 1.72 ng/mL, P < .0001). Serum (P < .001) and SF leptin (P = .004) concentrations were associated with BCS. Concentration of SF leptin did not differ between healthy (2.4 ± 2.04 ng/mL) and OA (4.9 ± 4.3 ng/mL, P = .25) dogs. Synovial fluid leptin and LOAD scores were weakly associated (P = .03). No association was detected between SF leptin and radiographic score or IL-1ß (P = .73).CONCLUSION:
Serum and SF leptin correlated with BCS in this population. Synovial fluid leptin was weakly associated with LOAD scores but not with radiographic severity of OA or IL-1ß. CLINICALSIGNIFICANCE:
Serum and SF leptin concentrations do not predict radiographic severity of canine OA but contribute to joint pain and dysfunction.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Arthrose
/
Synovie
/
Composition corporelle
/
Leptine
/
Maladies des chiens
Type d'étude:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites:
Animals
/
Female
/
Humans
/
Male
Langue:
En
Journal:
Vet Surg
Année:
2019
Type de document:
Article
Pays d'affiliation:
Géorgie