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Exploiting the 1-(4-fluorobenzyl)piperazine fragment for the development of novel tyrosinase inhibitors as anti-melanogenic agents: Design, synthesis, structural insights and biological profile.
Ielo, Laura; Deri, Batel; Germanò, Maria Paola; Vittorio, Serena; Mirabile, Salvatore; Gitto, Rosaria; Rapisarda, Antonio; Ronsisvalle, Simone; Floris, Sonia; Pazy, Yael; Fais, Antonella; Fishman, Ayelet; De Luca, Laura.
Affiliation
  • Ielo L; Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, Polo Universitario SS. Annunziata, University of Messina, Viale Palatucci 13, I-98168, Messina, Italy.
  • Deri B; Department of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, Haifa, 3200003, Israel.
  • Germanò MP; Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, Polo Universitario SS. Annunziata, University of Messina, Viale Palatucci 13, I-98168, Messina, Italy.
  • Vittorio S; Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, Polo Universitario SS. Annunziata, University of Messina, Viale Palatucci 13, I-98168, Messina, Italy.
  • Mirabile S; Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, Polo Universitario SS. Annunziata, University of Messina, Viale Palatucci 13, I-98168, Messina, Italy.
  • Gitto R; Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, Polo Universitario SS. Annunziata, University of Messina, Viale Palatucci 13, I-98168, Messina, Italy.
  • Rapisarda A; Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, Polo Universitario SS. Annunziata, University of Messina, Viale Palatucci 13, I-98168, Messina, Italy.
  • Ronsisvalle S; Department of Drug Science, Medicinal Chemistry Section University of Catania, Catania, Italy.
  • Floris S; Department of Life and Environment Sciences, University of Cagliari, I-09042, Monserrato, Cagliari, Italy.
  • Pazy Y; Technion Center for Structural Biology, Technion-Israel Institute of Technology, Haifa, 3200003, Israel.
  • Fais A; Department of Life and Environment Sciences, University of Cagliari, I-09042, Monserrato, Cagliari, Italy.
  • Fishman A; Department of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, Haifa, 3200003, Israel.
  • De Luca L; Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, Polo Universitario SS. Annunziata, University of Messina, Viale Palatucci 13, I-98168, Messina, Italy. Electronic address: ldeluca@unime.it.
Eur J Med Chem ; 178: 380-389, 2019 Sep 15.
Article de En | MEDLINE | ID: mdl-31202126
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pipérazines / Conception de médicament / Monophenol monooxygenase / Antienzymes / Antinéoplasiques Limites: Humans Langue: En Journal: Eur J Med Chem Année: 2019 Type de document: Article Pays d'affiliation: Italie Pays de publication: France
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pipérazines / Conception de médicament / Monophenol monooxygenase / Antienzymes / Antinéoplasiques Limites: Humans Langue: En Journal: Eur J Med Chem Année: 2019 Type de document: Article Pays d'affiliation: Italie Pays de publication: France