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Noncovalent inhibitors reveal BTK gatekeeper and auto-inhibitory residues that control its transforming activity.
Wang, Shenqiu; Mondal, Sayan; Zhao, Chunying; Berishaj, Marjan; Ghanakota, Phani; Batlevi, Connie Lee; Dogan, Ahmet; Seshan, Venkatraman E; Abel, Robert; Green, Michael R; Younes, Anas; Wendel, Hans-Guido.
Affiliation
  • Wang S; Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York USA.
  • Mondal S; Schrödinger, Inc., New York, New York, USA.
  • Zhao C; Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York USA.
  • Berishaj M; Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York USA.
  • Ghanakota P; Schrödinger, Inc., New York, New York, USA.
  • Batlevi CL; Department of Medicine Lymphoma Service.
  • Dogan A; Department of Pathology and Laboratory Medicine, and.
  • Seshan VE; Department of Epidemiology-Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
  • Abel R; Schrödinger, Inc., New York, New York, USA.
  • Green MR; Department of Lymphoma and Myeloma and Department of Genomic Medicine, University of Texas MD Anderson Cancer, Houston, Texas, USA.
  • Younes A; Department of Medicine Lymphoma Service.
  • Wendel HG; Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York USA.
JCI Insight ; 4(12)2019 06 20.
Article de En | MEDLINE | ID: mdl-31217352

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Antienzymes / Agammaglobulinaemia tyrosine kinase Type d'étude: Prognostic_studies Limites: Animals / Humans Langue: En Journal: JCI Insight Année: 2019 Type de document: Article Pays de publication: États-Unis d'Amérique

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Antienzymes / Agammaglobulinaemia tyrosine kinase Type d'étude: Prognostic_studies Limites: Animals / Humans Langue: En Journal: JCI Insight Année: 2019 Type de document: Article Pays de publication: États-Unis d'Amérique