Design of wogonin-inspired selective cyclin-dependent kinase 9 (CDK9) inhibitors with potent in vitro and in vivo antitumor activity.

Wang, Jubo; Li, Tinghan; Zhao, Tengteng; Wu, Tizhi; Liu, Chuang; Ding, Hong; Li, Zhiyu; Bian, Jinlei

Design of wogonin-inspired selective cyclin-dependent kinase 9 (CDK9) inhibitors with potent in vitro and in vivo antitumor activity.

Wang, Jubo; Li, Tinghan; Zhao, Tengteng; Wu, Tizhi; Liu, Chuang; Ding, Hong; Li, Zhiyu; Bian, Jinlei.

Affiliation

Wang J; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, 211198, China.
Li T; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, 211198, China.
Zhao T; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, 211198, China.
Wu T; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, 211198, China.
Liu C; Department of Biochemistry, China Pharmaceutical University, Nanjing 211198, China.
Ding H; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China.
Li Z; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, 211198, China. Electronic address: zhiyuli@cpu.edu.cn.
Bian J; Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, 211198, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China. Electronic address: bianjl@cpu.edu.cn.

Eur J Med Chem ; 178: 782-801, 2019 Sep 15.

Article de En | MEDLINE | ID: mdl-31238183

Sujet(s)
Mots clés

AML; Antitumor; CDK9; Flavonoid; Wogonin

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Conception de médicament / Flavanones / Inhibiteurs de protéines kinases / Antinéoplasiques Type d'étude: Observational_studies / Prognostic_studies Limites: Animals / Female / Humans Langue: En Journal: Eur J Med Chem Année: 2019 Type de document: Article Pays d'affiliation: Chine Pays de publication: France

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