A group sequential test for ABR detection.
Int J Audiol
; 58(10): 618-627, 2019 10.
Article
de En
| MEDLINE
| ID: mdl-31259611
ABSTRACT
Objective:
To detect the auditory brainstem response (ABR) automatically using an innovative sequentially applied Hotelling's T 2 test, with the overall goal of optimising test time whilst controlling the false-positive rate (FPR).Design:
The stage-wise critical decision boundaries for accepting or rejecting the null hypothesis were found using a new approach called the Convolutional Group Sequential Test (CGST). Specificity, sensitivity, and test time were evaluated using simulations and subject recorded data. Study sample Data consists of click-evoked ABR threshold series from 12 normal hearing adults, and recordings of EEG background activity from 17 normal hearing adults.Results:
Reductions in mean test time of up to 40-45% were observed for the sequential test, relative to a conventional "single shot" test where the statistical test is applied to the data just once. To obtain these results, it will occasionally be necessary to run the test to a higher number of stimuli, i.e. the maximum test time needs to be increased.Conclusions:
The CGST can be used to control the specificity of a sequentially applied ABR detection method. Doing so can reduce test time, relative to the "single shot" test, when considered across a cohort of test subjects.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Potentiels évoqués auditifs du tronc cérébral
/
Techniques de diagnostic neurologique
Type d'étude:
Diagnostic_studies
/
Evaluation_studies
Limites:
Humans
Langue:
En
Journal:
Int J Audiol
Sujet du journal:
AUDIOLOGIA
Année:
2019
Type de document:
Article
Pays d'affiliation:
Royaume-Uni