Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer.
BMC Biol
; 17(1): 52, 2019 07 04.
Article
de En
| MEDLINE
| ID: mdl-31272438
ABSTRACT
Altered metabolism and deregulated cellular energetics are now considered a hallmark of all cancers. Glucose, glutamine, fatty acids, and amino acids are the primary drivers of tumor growth and act as substrates for the hexosamine biosynthetic pathway (HBP). The HBP culminates in the production of an amino sugar uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) that, along with other charged nucleotide sugars, serves as the basis for biosynthesis of glycoproteins and other glycoconjugates. These nutrient-driven post-translational modifications are highly altered in cancer and regulate protein functions in various cancer-associated processes. In this review, we discuss recent progress in understanding the mechanistic relationship between the HBP and cancer.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Protéines
/
Maturation post-traductionnelle des protéines
/
Hexosamine
/
Tumeurs
Langue:
En
Journal:
BMC Biol
Sujet du journal:
BIOLOGIA
Année:
2019
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique