Development of the Intrahepatic and Extrahepatic Biliary Tract: A Framework for Understanding Congenital Diseases.
Annu Rev Pathol
; 15: 1-22, 2020 01 24.
Article
de En
| MEDLINE
| ID: mdl-31299162
ABSTRACT
The involvement of the biliary tract in the pathophysiology of liver diseases and the increased attention paid to bile ducts in the bioconstruction of liver tissue for regenerative therapy have fueled intense research into the fundamental mechanisms of biliary development. Here, I review the molecular, cellular and tissular mechanisms driving differentiation and morphogenesis of the intrahepatic and extrahepatic bile ducts. This review focuses on the dynamics of the transcriptional and signaling modules that promote biliary development in human and mouse liver and discusses studies in which the use of zebrafish uncovered unexplored processes in mammalian biliary development. The review concludes by providing a framework for interpreting the mechanisms that may help us understand the origin of congenital biliary diseases.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Conduits biliaires intrahépatiques
/
Voies biliaires
/
Conduits biliaires extrahépatiques
/
Maladies du foie
Limites:
Animals
/
Humans
Langue:
En
Journal:
Annu Rev Pathol
Sujet du journal:
PATOLOGIA
Année:
2020
Type de document:
Article