A Physiology-Inspired Multifactorial Toolbox in Soft-to-Hard Musculoskeletal Interface Tissue Engineering.
Trends Biotechnol
; 38(1): 83-98, 2020 01.
Article
de En
| MEDLINE
| ID: mdl-31320120
ABSTRACT
Musculoskeletal diseases are increasing the prevalence of physical disability worldwide. Within the body, musculoskeletal soft and hard tissues integrate through specific multitissue transitions, allowing for body movements. Owing to their unique compositional and structural gradients, injuries challenge the native interfaces and tissue regeneration is unlikely to occur. Tissue engineering strategies are emerging to emulate the physiological environment of soft-to-hard tissue interfaces. Advances in biomaterial design enable control over biophysical parameters, but biomaterials alone are not sufficient to provide adequate support and guide transplanted cells. Therefore, biological, biophysical, and biochemical tools can be integrated into a multifactorial toolbox, steering prospective advances toward engineering clinically relevant soft-to-hard tissue interfaces.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Logiciel
/
Ingénierie tissulaire
/
Phénomènes biophysiques
/
Appareil locomoteur
/
Phénomènes physiologiques du système locomoteur
Type d'étude:
Risk_factors_studies
Limites:
Animals
/
Humans
Langue:
En
Journal:
Trends Biotechnol
Année:
2020
Type de document:
Article