Antimalarial activity of primaquine operates via a two-step biochemical relay.

Camarda, Grazia; Jirawatcharadech, Piyaporn; Priestley, Richard S; Saif, Ahmed; March, Sandra; Wong, Michael H L; Leung, Suet; Miller, Alex B; Baker, David A; Alano, Pietro; Paine, Mark J I; Bhatia, Sangeeta N; O'Neill, Paul M; Ward, Stephen A; Biagini, Giancarlo A

Camarda, Grazia; Jirawatcharadech, Piyaporn; Priestley, Richard S; Saif, Ahmed; March, Sandra; Wong, Michael H L; Leung, Suet; Miller, Alex B; Baker, David A; Alano, Pietro; Paine, Mark J I; Bhatia, Sangeeta N; O'Neill, Paul M; Ward, Stephen A; Biagini, Giancarlo A.

Affiliation

Camarda G; Centre for Drugs and Diagnostics Research, Tropical Disease Biology Department, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK.
Jirawatcharadech P; Centre for Drugs and Diagnostics Research, Tropical Disease Biology Department, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK.
Priestley RS; Centre for Drugs and Diagnostics Research, Tropical Disease Biology Department, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK.
Saif A; ARUK Oxford Drug Discovery Institute, University of Oxford, Oxford, OX3 7FZ, UK.
March S; Centre for Drugs and Diagnostics Research, Tropical Disease Biology Department, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK.
Wong MHL; Clinical Laboratory sciences Department, College of Applied Medical Sciences, Najran University, Najran, 61441, Saudi Arabia.
Leung S; Health Sciences and Technology/Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Miller AB; Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, UK.
Baker DA; Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, UK.
Alano P; Health Sciences and Technology/Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Paine MJI; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK.
Bhatia SN; Dipartimento di Malattie Infettive, Istituto Superiore di Sanità, Rome, 00161, Italy.
O'Neill PM; Vector Biology Department, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK.
Ward SA; Health Sciences and Technology/Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Biagini GA; Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, UK.

Nat Commun ; 10(1): 3226, 2019 07 19.

Article de En | MEDLINE | ID: mdl-31324806

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Plasmodium falciparum / Primaquine / Antipaludiques Limites: Humans Langue: En Journal: Nat Commun Sujet du journal: BIOLOGIA / CIENCIA Année: 2019 Type de document: Article Pays d'affiliation: Royaume-Uni

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