A simple and rapid method of inducing physical dependence with benzodiazepines in mice.
Pharmacol Biochem Behav
; 29(4): 753-4, 1988 Apr.
Article
de En
| MEDLINE
| ID: mdl-3137588
ABSTRACT
Physical dependence was rapidly induced in mice by administering diazepam intraperitoneally twice daily using an incremental dosing regimen (50 to 450 mg/kg) for nine consecutive days. Withdrawal was induced (24 hr after the last dose) by administration of a benzodiazepine antagonist, RO-15-1788 (10 mg/kg, IP). All of the mice exhibited clear-cut withdrawal symptoms (i.e., convulsions) within minutes of antagonist treatment. This method offers a simple, reliable, high throughput procedure for the assessment of benzodiazepine-like physical dependence liability and withdrawal, and it would be useful for screening purposes.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Benzodiazépines
/
Troubles liés à une substance
Limites:
Animals
Langue:
En
Journal:
Pharmacol Biochem Behav
Année:
1988
Type de document:
Article