Interstitial and external radiotherapy in carcinoma of the soft palate and uvula.
Int J Radiat Oncol Biol Phys
; 15(3): 619-25, 1988 Sep.
Article
de En
| MEDLINE
| ID: mdl-3138213
ABSTRACT
Forty-three patients, all male, with limited epidermoid carcinoma of the soft palate and uvula were treated by interstitial implant usually associated with external radiotherapy. Most patients received 50 Gy external irradiation to the oropharynx and neck followed by 20-35 Gy by interstitial iridium-192 wires using either guide gutters or a plastic tube technique. Twelve primary tumors and two recurrences after external irradiation alone had implant only for 65-75 Gy. Total actuarial local control is 92% with no local failures in 34 T1 primary tumors. Only one serious complication was seen. Overall actuarial survival was 60% at 3 years and 37% at 5 years but cause-specific survivals were 81% and 64%. The leading cause of death was other aerodigestive cancer, with an actuarial rate of occurrence of 10% per year after treatment of a soft palate cancer. Interstitital brachytherapy alone or combined with external irradiation is safe, effective management for early carcinoma of the soft palate and uvula but second malignancy is a serious problem.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Palais mou
/
Luette
/
Curiethérapie
/
Radio-isotopes de l'iridium
/
Carcinome épidermoïde
/
Tumeurs du palais
/
Radiothérapie de haute énergie
Limites:
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Int J Radiat Oncol Biol Phys
Année:
1988
Type de document:
Article
Pays d'affiliation:
France