Oligodendrocytes in intracerebral hemorrhage.
CNS Neurosci Ther
; 25(10): 1075-1084, 2019 10.
Article
de En
| MEDLINE
| ID: mdl-31410988
ABSTRACT
Intracerebral hemorrhage (ICH) is a cerebrovascular disorder with high mortality and disability rates. Although a lot of effort has been put in ICH, there is still no effective treatment for this devastating disease. Recent studies suggest that oligodendrocytes play an important role in brain repair after ICH and thus may be targeted for the therapies of ICH. Here in this review, we first introduce the origin, migration, proliferation, differentiation, and myelination of oligodendrocytes under physiological condition. Second, recent findings on how ICH affects oligodendrocyte biology and function are reviewed. Third, potential crosstalk between oligodendrocytes and other cells in the brain is also summarized. Last, we discuss the therapeutic potential of oligodendrocyte-based treatments in ICH. Our goal is to provide a comprehensive review on the biology and function of oligodendrocytes under both physiological and ICH conditions.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Encéphale
/
Hémorragie cérébrale
/
Oligodendroglie
Type d'étude:
Diagnostic_studies
Limites:
Humans
Langue:
En
Journal:
CNS Neurosci Ther
Sujet du journal:
NEUROLOGIA
/
TERAPEUTICA
Année:
2019
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique