Achieving Mucosal Healing in Inflammatory Bowel Diseases: Which Drug Concentrations Need to Be Targeted?
Clin Pharmacol Ther
; 106(5): 945-954, 2019 11.
Article
de En
| MEDLINE
| ID: mdl-31420861
ABSTRACT
Biologicals introduced a major shift in the treatment of patients suffering from inflammatory bowel diseases. Despite providing a tight disease control for many patients, a considerable proportion of patients will fail to respond favorably to treatment or will lose response over time. Therapeutic drug monitoring emerged as a valuable tool to guide clinical decision making as serum drug concentrations have been linked to outcomes. Focusing on mucosal healing as the ultimate treatment goal, different drug concentration thresholds to achieve this outcome have been identified in the literature and are summarized in this review. For therapeutic drug monitoring to be successful in guiding clinical decision making, the used assay, the sampling time point, and the outcome that is aimed for should be taken into account when interpreting drug concentration thresholds. Awareness of these essential aspects among clinicians will improve the implementation of therapeutic drug monitoring and aid in making an evidence-based decision.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Produits biologiques
/
Maladies inflammatoires intestinales
/
Surveillance des médicaments
/
Muqueuse intestinale
Type d'étude:
Prognostic_studies
Limites:
Humans
Langue:
En
Journal:
Clin Pharmacol Ther
Année:
2019
Type de document:
Article
Pays d'affiliation:
Belgique