Airflow limitation and survival after surgery for non-small cell lung cancer: Results from a systematic review and lung cancer screening trial (NLST-ACRIN sub-study).
Lung Cancer
; 135: 80-87, 2019 09.
Article
de En
| MEDLINE
| ID: mdl-31447006
ABSTRACT
OBJECTIVE:
Lung cancer remains the single greatest cause of cancer mortality where surgery for early stage non-small cell lung cancer achieves the greatest survival. While there is growing optimism for better outcomes with screening using annual computed tomography, the impact of co-existing airflow limitation on survival remains unknown. To compare survival in non-small cell lung cancer patients undergoing surgery stratified according to the presence or absence of pre-surgery airflow limitation. MATERIALS ANDMETHODS:
We undertook a systematic literature search of non-screen lung cancer that encompassed studies reported between January 1946 and January 2017. Full-text articles were identified following eligibility scoring, with data extracted and analysed using a standardised analytical method (PRISMA). The results of this systematic review in non-screen lung cancers were compared to real-world results from a lung cancer screening cohort (Nâ¯=â¯10,054), where outcomes following surgery could be compared after stratification according to pre-surgery airflow limitation.RESULTS:
In the systematic review, 6899 subjects were included from 10 studies; 7 were retrospective, 3 were prospective. Overall survival was 950 (44%) in 2144 people with COPD and 2597 (55%) from 4755 controls (unadjusted P value <0.001). However, the overall meta-analysed random effects odds ratio for overall survival (Nâ¯=â¯10) and 5-year survival (Nâ¯=â¯4) comparing those with and without COPD was 0.91 (95% CIâ¯=â¯0.84-1.00) and 0.99 (95% CIâ¯=â¯0.79-1.24) respectively. There were no signs of significant heterogeneity (I2â¯=â¯19.1%, Pâ¯=â¯0.27) nor publication bias as assessed by funnel plot and Egger's test (Pâ¯=â¯0.19). In the lung cancer screening sub-study of 10,054 screening participants we found no difference in 5-year survival in those with and without airflow limitation (84% and 81% respectively, Pâ¯=â¯0.64).CONCLUSION:
Survival after surgery for non-small cell lung cancer is comparable between those with and without spirometry evidence of airflow limitation. This finding was replicated in lung cancer diagnosed during screening.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Carcinome pulmonaire non à petites cellules
/
Tumeurs du poumon
Type d'étude:
Diagnostic_studies
/
Etiology_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
/
Systematic_reviews
Limites:
Humans
Langue:
En
Journal:
Lung Cancer
Sujet du journal:
NEOPLASIAS
Année:
2019
Type de document:
Article
Pays d'affiliation:
Nouvelle-Zélande