BRAF inhibitors promote intermediate BRAF(V600E) conformations and binary interactions with activated RAS.

Röck, Ruth; Mayrhofer, Johanna E; Torres-Quesada, Omar; Enzler, Florian; Raffeiner, Andrea; Raffeiner, Philipp; Feichtner, Andreas; Huber, Roland G; Koide, Shohei; Taylor, Susan S; Troppmair, Jakob; Stefan, Eduard

Röck, Ruth; Mayrhofer, Johanna E; Torres-Quesada, Omar; Enzler, Florian; Raffeiner, Andrea; Raffeiner, Philipp; Feichtner, Andreas; Huber, Roland G; Koide, Shohei; Taylor, Susan S; Troppmair, Jakob; Stefan, Eduard.

Affiliation

Röck R; Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
Mayrhofer JE; Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
Torres-Quesada O; Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
Enzler F; Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
Raffeiner A; Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
Raffeiner P; Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
Feichtner A; Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
Huber RG; Bioinformatics Institute (BII), Agency for Science Technology and Research (ASTAR), Singapore 138671, Singapore.
Koide S; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine and Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY 10016, USA.
Taylor SS; Department of Pharmacology, Department of Chemistry and Biochemistry, and Howard Hughes Medical Institute, University of California, San Diego, San Diego, CA 92093, USA.
Troppmair J; Daniel Swarovski Research Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innrain 66, 6020 Innsbruck, Austria.
Stefan E; Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.

Sci Adv ; 5(8): eaav8463, 2019 08.

Article de En | MEDLINE | ID: mdl-31453322

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Protéines proto-oncogènes p21(ras) / Protéines proto-oncogènes B-raf / Inhibiteurs de protéines kinases / Mélanome Limites: Humans Langue: En Journal: Sci Adv Année: 2019 Type de document: Article Pays d'affiliation: Autriche

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