Formation of Alcohol Motivation in Monkeys (Macaca mulatta) Kept in Isolation.
Bull Exp Biol Med
; 167(4): 516-520, 2019 Aug.
Article
de En
| MEDLINE
| ID: mdl-31494767
ABSTRACT
The effects of environmental factors (flavors, different ethanol concentration, alcoholic deprivation, and food reinforcement) on the formation of alcohol motivation was studied in rhesus macaques (Macaca mulatta, n=6). Motivation for alcohol intake was induced in two stages initiation (sessions 1-160) and formation of motivation (sessions 161-516). Monkeys preferred multifruit flavor and 4% ethanol solution, while ethanol deprivation did not stimulate alcohol consumption. The pronounced individual differences in the pattern of alcohol motivation were revealed the intake of 4% ethanol solution ranged from 0.21±0.03 to 0.43±0.06 g/kg without food reinforcement and increased from 0.78±0.03 to 1.22±0.09 g/kg with food reinforcement. The results suggest that the proposed method is valid and can be used as an experimental model of alcohol dependence in non-human primates.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Éthanol
/
Motivation
Type d'étude:
Prognostic_studies
Limites:
Animals
Langue:
En
Journal:
Bull Exp Biol Med
Année:
2019
Type de document:
Article
Pays d'affiliation:
Russie