ITGA5 inhibition in pancreatic stellate cells attenuates desmoplasia and potentiates efficacy of chemotherapy in pancreatic cancer.

Kuninty, Praneeth R; Bansal, Ruchi; De Geus, Susanna W L; Mardhian, Deby F; Schnittert, Jonas; van Baarlen, Joop; Storm, Gert; Bijlsma, Maarten F; van Laarhoven, Hanneke W; Metselaar, Josbert M; Kuppen, Peter J K; Vahrmeijer, Alexander L; Östman, Arne; Sier, Cornelis F M; Prakash, Jai

Kuninty, Praneeth R; Bansal, Ruchi; De Geus, Susanna W L; Mardhian, Deby F; Schnittert, Jonas; van Baarlen, Joop; Storm, Gert; Bijlsma, Maarten F; van Laarhoven, Hanneke W; Metselaar, Josbert M; Kuppen, Peter J K; Vahrmeijer, Alexander L; Östman, Arne; Sier, Cornelis F M; Prakash, Jai.

Affiliation

Kuninty PR; Department of Biomaterials, Science and Technology, Section: Targeted Therapeutics, Faculty of Science and Technology, University of Twente, Enschede, Netherlands.
Bansal R; Department of Biomaterials, Science and Technology, Section: Targeted Therapeutics, Faculty of Science and Technology, University of Twente, Enschede, Netherlands.
De Geus SWL; Department of Surgery, Leiden University Medical Center, Leiden, Netherlands.
Mardhian DF; Department of Biomaterials, Science and Technology, Section: Targeted Therapeutics, Faculty of Science and Technology, University of Twente, Enschede, Netherlands.
Schnittert J; Department of Biomaterials, Science and Technology, Section: Targeted Therapeutics, Faculty of Science and Technology, University of Twente, Enschede, Netherlands.
van Baarlen J; Laboratory Pathology Oost Netherlands (LabPON), Hengelo, Netherlands.
Storm G; Department of Biomaterials, Science and Technology, Section: Targeted Therapeutics, Faculty of Science and Technology, University of Twente, Enschede, Netherlands.
Bijlsma MF; Department of Pharmaceutics, Utrecht University, Utrecht, Netherlands.
van Laarhoven HW; Amsterdam University Medical Centre, University of Amsterdam, Amsterdam, Netherlands.
Metselaar JM; Amsterdam University Medical Centre, University of Amsterdam, Amsterdam, Netherlands.
Kuppen PJK; ScarTec Therapeutics BV, Enschede, Netherlands.
Vahrmeijer AL; Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, RWTH University Clinic, Forckenbeckstrasse 55, 52074 Aachen, Germany.
Östman A; Department of Surgery, Leiden University Medical Center, Leiden, Netherlands.
Sier CFM; Department of Surgery, Leiden University Medical Center, Leiden, Netherlands.
Prakash J; Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden.

Sci Adv ; 5(9): eaax2770, 2019 09.

Article de En | MEDLINE | ID: mdl-31517053

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Tumeurs du pancréas / Intégrines / Carcinome du canal pancréatique / Cellules stellaires pancréatiques / Peptidomimétiques / Protéines tumorales Limites: Animals / Humans / Male Langue: En Journal: Sci Adv Année: 2019 Type de document: Article Pays d'affiliation: Pays-Bas

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