Systematic Identification of Host Cell Regulators of Legionella pneumophila Pathogenesis Using a Genome-wide CRISPR Screen.

Jeng, Edwin E; Bhadkamkar, Varun; Ibe, Nnejiuwa U; Gause, Haley; Jiang, Lihua; Chan, Joanne; Jian, Ruiqi; Jimenez-Morales, David; Stevenson, Erica; Krogan, Nevan J; Swaney, Danielle L; Snyder, Michael P; Mukherjee, Shaeri; Bassik, Michael C

Jeng, Edwin E; Bhadkamkar, Varun; Ibe, Nnejiuwa U; Gause, Haley; Jiang, Lihua; Chan, Joanne; Jian, Ruiqi; Jimenez-Morales, David; Stevenson, Erica; Krogan, Nevan J; Swaney, Danielle L; Snyder, Michael P; Mukherjee, Shaeri; Bassik, Michael C.

Affiliation

Jeng EE; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Program in Cancer Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Bhadkamkar V; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Ibe NU; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Gause H; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
Jiang L; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Chan J; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jian R; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jimenez-Morales D; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA; The J. David Gladstone Institutes, San Francisco, CA, USA.
Stevenson E; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA; The J. David Gladstone Institutes, San Francisco, CA, USA.
Krogan NJ; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA; The J. David Gladstone Institutes, San Francisco, CA, USA.
Swaney DL; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA, USA; The J. David Gladstone Institutes, San Francisco, CA, USA.
Snyder MP; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Mukherjee S; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: shaeri.mukherjee@ucsf.edu.
Bassik MC; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: bassik@stanford.edu.

Cell Host Microbe ; 26(4): 551-563.e6, 2019 10 09.

Article de En | MEDLINE | ID: mdl-31540829

Sujet(s)
Mots clés

C1ORF43; CRISPR screen; Legionella pneumophila; RAB10; host-pathogen interaction; intracellular bacteria; pathogen; phagocytosis

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Phagocytose / Vacuoles / Maladie des légionnaires / Protéines / Legionella pneumophila Type d'étude: Diagnostic_studies / Etiology_studies / Prognostic_studies Limites: Animals / Humans Langue: En Journal: Cell Host Microbe Sujet du journal: MICROBIOLOGIA Année: 2019 Type de document: Article Pays d'affiliation: États-Unis d'Amérique

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