Discovery of an Extremely Potent Thiazine-Based ß-Secretase Inhibitor with Reduced Cardiovascular and Liver Toxicity at a Low Projected Human Dose.

Tadano, Genta; Komano, Kazuo; Yoshida, Shuhei; Suzuki, Shinji; Nakahara, Kenji; Fuchino, Kouki; Fujimoto, Kazuki; Matsuoka, Eriko; Yamamoto, Takahiko; Asada, Naoya; Ito, Hisanori; Sakaguchi, Gaku; Kanegawa, Naoki; Kido, Yasuto; Ando, Shigeru; Fukushima, Tamio; Teisman, Ard; Urmaliya, Vijay; Dhuyvetter, Deborah; Borghys, Herman; Van Den Bergh, An; Austin, Nigel; Gijsen, Harrie J M; Yamano, Yoshinori; Iso, Yasuyoshi; Kusakabe, Ken-Ichi

Tadano, Genta; Komano, Kazuo; Yoshida, Shuhei; Suzuki, Shinji; Nakahara, Kenji; Fuchino, Kouki; Fujimoto, Kazuki; Matsuoka, Eriko; Yamamoto, Takahiko; Asada, Naoya; Ito, Hisanori; Sakaguchi, Gaku; Kanegawa, Naoki; Kido, Yasuto; Ando, Shigeru; Fukushima, Tamio; Teisman, Ard; Urmaliya, Vijay; Dhuyvetter, Deborah; Borghys, Herman; Van Den Bergh, An; Austin, Nigel; Gijsen, Harrie J M; Yamano, Yoshinori; Iso, Yasuyoshi; Kusakabe, Ken-Ichi.

J Med Chem ; 62(20): 9331-9337, 2019 10 24.

Article de En | MEDLINE | ID: mdl-31549838

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Inhibiteurs de protéases / Thiazines / Amyloid precursor protein secretases Limites: Animals / Female / Humans / Male Langue: En Journal: J Med Chem Sujet du journal: QUIMICA Année: 2019 Type de document: Article Pays de publication: États-Unis d'Amérique

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