Effects of new C6-substituted steroidal aromatase inhibitors in hormone-sensitive breast cancer cells: Cell death mechanisms and modulation of estrogen and androgen receptors.

Augusto, Tiago V; Amaral, Cristina; Varela, Carla L; Bernardo, Fernanda; da Silva, Elisiário Tavares; Roleira, Fernanda F M; Costa, Saul; Teixeira, Natércia; Correia-da-Silva, Georgina

Augusto, Tiago V; Amaral, Cristina; Varela, Carla L; Bernardo, Fernanda; da Silva, Elisiário Tavares; Roleira, Fernanda F M; Costa, Saul; Teixeira, Natércia; Correia-da-Silva, Georgina.

Affiliation

Augusto TV; Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal; UCIBIO.REQUIMTE, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
Amaral C; Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal; UCIBIO.REQUIMTE, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
Varela CL; Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal; CIEPQPF Centre for Chemical Processes Engineering and Forest Products, University of Coimbra, 3030-790 Coimbra, Portugal.
Bernardo F; Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
da Silva ET; Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal; CIEPQPF Centre for Chemical Processes Engineering and Forest Products, University of Coimbra, 3030-790 Coimbra, Portugal.
Roleira FFM; Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal; CIEPQPF Centre for Chemical Processes Engineering and Forest Products, University of Coimbra, 3030-790 Coimbra, Portugal.
Costa S; Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal; CIEPQPF Centre for Chemical Processes Engineering and Forest Products, University of Coimbra, 3030-790 Coimbra, Portugal.
Teixeira N; Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal; UCIBIO.REQUIMTE, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal. Electronic address: n
Correia-da-Silva G; Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal; UCIBIO.REQUIMTE, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal. Electronic address: g

J Steroid Biochem Mol Biol ; 195: 105486, 2019 12.

Article de En | MEDLINE | ID: mdl-31557516

Sujet(s)
Mots clés

Androgen receptor; Anti-Cancer properties; Aromatase; Aromatase inhibitors; Breast cancer; C6-substituted androstanes; Estrogen receptor

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Tumeurs du sein / Aromatase / Récepteurs aux androgènes / Récepteur alpha des oestrogènes / Inhibiteurs de l'aromatase Type d'étude: Diagnostic_studies Limites: Female / Humans Langue: En Journal: J Steroid Biochem Mol Biol Sujet du journal: BIOLOGIA MOLECULAR / BIOQUIMICA Année: 2019 Type de document: Article Pays d'affiliation: Portugal Pays de publication: Royaume-Uni

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