Discovery of a Furanopyrimidine-Based Epidermal Growth Factor Receptor Inhibitor (DBPR112) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer.

Lin, Shu-Yu; Chang Hsu, Yung; Peng, Yi-Hui; Ke, Yi-Yu; Lin, Wen-Hsing; Sun, Hsu-Yi; Shiao, Hui-Yi; Kuo, Fu-Ming; Chen, Pei-Yi; Lien, Tzu-Wen; Chen, Chun-Hwa; Chu, Chang-Ying; Wang, Sing-Yi; Yeh, Kai-Chia; Chen, Ching-Ping; Hsu, Tsu-An; Wu, Su-Ying; Yeh, Teng-Kuang; Chen, Chiung-Tong; Hsieh, Hsing-Pang

Lin, Shu-Yu; Chang Hsu, Yung; Peng, Yi-Hui; Ke, Yi-Yu; Lin, Wen-Hsing; Sun, Hsu-Yi; Shiao, Hui-Yi; Kuo, Fu-Ming; Chen, Pei-Yi; Lien, Tzu-Wen; Chen, Chun-Hwa; Chu, Chang-Ying; Wang, Sing-Yi; Yeh, Kai-Chia; Chen, Ching-Ping; Hsu, Tsu-An; Wu, Su-Ying; Yeh, Teng-Kuang; Chen, Chiung-Tong; Hsieh, Hsing-Pang.

Affiliation

Lin SY; Institute of Biotechnology and Pharmaceutical Research , National Health Research Institutes , 35 Keyan Road , Zhunan, Miaoli County 35053 , Taiwan , ROC.
Chang Hsu Y; Institute of Biotechnology and Pharmaceutical Research , National Health Research Institutes , 35 Keyan Road , Zhunan, Miaoli County 35053 , Taiwan , ROC.
Peng YH; Institute of Biotechnology and Pharmaceutical Research , National Health Research Institutes , 35 Keyan Road , Zhunan, Miaoli County 35053 , Taiwan , ROC.
Ke YY; Institute of Biotechnology and Pharmaceutical Research , National Health Research Institutes , 35 Keyan Road , Zhunan, Miaoli County 35053 , Taiwan , ROC.
Lin WH; Institute of Biotechnology and Pharmaceutical Research , National Health Research Institutes , 35 Keyan Road , Zhunan, Miaoli County 35053 , Taiwan , ROC.
Sun HY; Institute of Biotechnology and Pharmaceutical Research , National Health Research Institutes , 35 Keyan Road , Zhunan, Miaoli County 35053 , Taiwan , ROC.
Shiao HY; Institute of Biotechnology and Pharmaceutical Research , National Health Research Institutes , 35 Keyan Road , Zhunan, Miaoli County 35053 , Taiwan , ROC.
Kuo FM; Institute of Biotechnology and Pharmaceutical Research , National Health Research Institutes , 35 Keyan Road , Zhunan, Miaoli County 35053 , Taiwan , ROC.
Chen PY; Institute of Biotechnology and Pharmaceutical Research , National Health Research Institutes , 35 Keyan Road , Zhunan, Miaoli County 35053 , Taiwan , ROC.
Lien TW; Institute of Biotechnology and Pharmaceutical Research , National Health Research Institutes , 35 Keyan Road , Zhunan, Miaoli County 35053 , Taiwan , ROC.
Chen CH; Institute of Biotechnology and Pharmaceutical Research , National Health Research Institutes , 35 Keyan Road , Zhunan, Miaoli County 35053 , Taiwan , ROC.
Chu CY; Institute of Biotechnology and Pharmaceutical Research , National Health Research Institutes , 35 Keyan Road , Zhunan, Miaoli County 35053 , Taiwan , ROC.
Wang SY; Institute of Biotechnology and Pharmaceutical Research , National Health Research Institutes , 35 Keyan Road , Zhunan, Miaoli County 35053 , Taiwan , ROC.
Yeh KC; Institute of Biotechnology and Pharmaceutical Research , National Health Research Institutes , 35 Keyan Road , Zhunan, Miaoli County 35053 , Taiwan , ROC.
Chen CP; Institute of Biotechnology and Pharmaceutical Research , National Health Research Institutes , 35 Keyan Road , Zhunan, Miaoli County 35053 , Taiwan , ROC.
Hsu TA; Institute of Biotechnology and Pharmaceutical Research , National Health Research Institutes , 35 Keyan Road , Zhunan, Miaoli County 35053 , Taiwan , ROC.
Wu SY; Institute of Biotechnology and Pharmaceutical Research , National Health Research Institutes , 35 Keyan Road , Zhunan, Miaoli County 35053 , Taiwan , ROC.
Yeh TK; Institute of Biotechnology and Pharmaceutical Research , National Health Research Institutes , 35 Keyan Road , Zhunan, Miaoli County 35053 , Taiwan , ROC.
Chen CT; Institute of Biotechnology and Pharmaceutical Research , National Health Research Institutes , 35 Keyan Road , Zhunan, Miaoli County 35053 , Taiwan , ROC.
Hsieh HP; Institute of Biotechnology and Pharmaceutical Research , National Health Research Institutes , 35 Keyan Road , Zhunan, Miaoli County 35053 , Taiwan , ROC.

J Med Chem ; 62(22): 10108-10123, 2019 11 27.

Article de En | MEDLINE | ID: mdl-31560541

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Carcinome pulmonaire non à petites cellules / Inhibiteurs de protéines kinases / Tumeurs du poumon / Antinéoplasiques Type d'étude: Prognostic_studies Limites: Animals / Humans / Male Langue: En Journal: J Med Chem Sujet du journal: QUIMICA Année: 2019 Type de document: Article Pays de publication: États-Unis d'Amérique

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