DIBI, a novel 3-hydroxypyridin-4-one chelator iron-binding polymer, inhibits breast cancer cell growth and functions as a chemosensitizer by promoting S-phase DNA damage.

Greenshields, Anna L; Power Coombs, Melanie R; Fernando, Wasundara; Holbein, Bruce E; Hoskin, David W

Greenshields, Anna L; Power Coombs, Melanie R; Fernando, Wasundara; Holbein, Bruce E; Hoskin, David W.

Affiliation

Greenshields AL; Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.
Power Coombs MR; Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.
Fernando W; Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.
Holbein BE; Chelation Partners Inc., Guelph, ON, Canada.
Hoskin DW; Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada. d.w.hoskin@dal.ca.

Biometals ; 32(6): 909-921, 2019 12.

Article de En | MEDLINE | ID: mdl-31624972

Sujet(s)
Mots clés

Breast cancer; Chemotherapy; DNA damage; Iron chelation

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Polymères / Pyridines / Pyridones / Altération de l'ADN / Tumeurs du sein / Agents chélateurs du fer / Phase S / Antinéoplasiques Limites: Female / Humans Langue: En Journal: Biometals Sujet du journal: BIOQUIMICA Année: 2019 Type de document: Article Pays d'affiliation: Canada Pays de publication: Pays-Bas

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