A kinase-independent role for CDK8 in BCR-ABL1<sup>+</sup> leukemia.

Menzl, Ingeborg; Zhang, Tinghu; Berger-Becvar, Angelika; Grausenburger, Reinhard; Heller, Gerwin; Prchal-Murphy, Michaela; Edlinger, Leo; Knab, Vanessa M; Uras, Iris Z; Grundschober, Eva; Bauer, Karin; Roth, Mareike; Skucha, Anna; Liu, Yao; Hatcher, John M; Liang, Yanke; Kwiatkowski, Nicholas P; Fux, Daniela; Hoelbl-Kovacic, Andrea; Kubicek, Stefan; Melo, Junia V; Valent, Peter; Weichhart, Thomas; Grebien, Florian; Zuber, Johannes; Gray, Nathanael S; Sexl, Veronika

A kinase-independent role for CDK8 in BCR-ABL1⁺ leukemia.

Menzl, Ingeborg; Zhang, Tinghu; Berger-Becvar, Angelika; Grausenburger, Reinhard; Heller, Gerwin; Prchal-Murphy, Michaela; Edlinger, Leo; Knab, Vanessa M; Uras, Iris Z; Grundschober, Eva; Bauer, Karin; Roth, Mareike; Skucha, Anna; Liu, Yao; Hatcher, John M; Liang, Yanke; Kwiatkowski, Nicholas P; Fux, Daniela; Hoelbl-Kovacic, Andrea; Kubicek, Stefan; Melo, Junia V; Valent, Peter; Weichhart, Thomas; Grebien, Florian; Zuber, Johannes; Gray, Nathanael S; Sexl, Veronika.

Affiliation

Menzl I; Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.
Zhang T; Department of Cancer Biology, Department of Biological Chemistry and Molecular Pharmacology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
Berger-Becvar A; Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.
Grausenburger R; Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.
Heller G; Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.
Prchal-Murphy M; Department of Medicine I, Medical University of Vienna, Vienna, Austria.
Edlinger L; Comprehensive Cancer Center, Vienna, Austria.
Knab VM; Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.
Uras IZ; Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.
Grundschober E; Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.
Bauer K; Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.
Roth M; Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.
Skucha A; Division of Hematology and Hemostaseology, Department of Internal Medicine I, Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria.
Liu Y; Research Institute of Molecular Pathology, Campus-Vienna-Biocenter 1, Vienna, Austria.
Hatcher JM; Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria.
Liang Y; Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Kwiatkowski NP; Department of Cancer Biology, Department of Biological Chemistry and Molecular Pharmacology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
Fux D; Department of Cancer Biology, Department of Biological Chemistry and Molecular Pharmacology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
Hoelbl-Kovacic A; Department of Cancer Biology, Department of Biological Chemistry and Molecular Pharmacology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
Kubicek S; Department of Cancer Biology, Department of Biological Chemistry and Molecular Pharmacology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
Melo JV; Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.
Valent P; Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.
Weichhart T; Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Grebien F; Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia, 5005, Australia.
Zuber J; Department of Hematology, Imperial College London, Kensington, London, SW7 2AZ, UK.
Gray NS; Division of Hematology and Hemostaseology, Department of Internal Medicine I, Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria.
Sexl V; Center of Pathobiochemistry and Genetics, Institute of Medical Genetics, Medical University of Vienna, Vienna, Austria.

Nat Commun ; 10(1): 4741, 2019 10 18.

Article de En | MEDLINE | ID: mdl-31628323

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Leucémie-lymphome lymphoblastique à précurseurs B / Protéines de fusion bcr-abl / Modèles animaux de maladie humaine / Cyclin-Dependent Kinase 8 Limites: Animals / Humans Langue: En Journal: Nat Commun Sujet du journal: BIOLOGIA / CIENCIA Année: 2019 Type de document: Article Pays d'affiliation: Autriche Pays de publication: Royaume-Uni

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