Immune Complexes Impaired Glomerular Endothelial Cell Functions in Lupus Nephritis.
Int J Mol Sci
; 20(21)2019 Oct 24.
Article
de En
| MEDLINE
| ID: mdl-31652980
ABSTRACT
Lupus nephritis (LN) is one of the most common and severe complications of lupus. However, the mechanisms for renal damage have not been well elucidated. There are evidences show that glomerular endothelial cells (GECs) are damaged in LN. Immune complexes can deposit in subendothelial area and could affect GEC functions. In the present study, we used heat-aggregated gamma globulin (HAGG) to simulate immune complexes and investigated their effects on GEC functions. Our results revealed that HAGG impaired different aspect of the GEC functions. HAGG changed cell morphology, upregulated the expression of active caspase-3, inhibited angiogenesis, and increased NO production in GECs. These results provide new clues for the mechanisms of renal damage and the pathology of LN.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Glomérulonéphrite lupique
/
Gammaglobulines
/
Cellules endothéliales
Limites:
Humans
Langue:
En
Journal:
Int J Mol Sci
Année:
2019
Type de document:
Article
Pays d'affiliation:
Chine