Filovirus-reactive antibodies in humans and bats in Northeast India imply zoonotic spillover.
PLoS Negl Trop Dis
; 13(10): e0007733, 2019 10.
Article
de En
| MEDLINE
| ID: mdl-31671094
ABSTRACT
Bats are reservoirs for several zoonotic pathogens, including filoviruses. Recent work highlights the diversity of bat borne filoviruses in Asia. High risk activities at the bat-human interface pose the threat of zoonotic virus transmission. We present evidence for prior exposure of bat harvesters and two resident fruit bat species to filovirus surface glycoproteins by screening sera in a multiplexed serological assay. Antibodies reactive to two antigenically distinct filoviruses were detected in human sera and to three individual filoviruses in bats in remote Northeast India. Sera obtained from Eonycteris spelaea bats showed similar patterns of cross-reactivity as human samples, suggesting them as the species responsible for the spillover. In contrast, sera from Rousettus leschenaultii bats reacted to two different virus glycoproteins. Our results indicate circulation of several filoviruses in bats and the possibility for filovirus transmission from bats to humans.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Réservoirs de maladies
/
Chiroptera
/
Filoviridae
/
Infections à Filoviridae
/
Anticorps antiviraux
Limites:
Adolescent
/
Adult
/
Animals
/
Humans
/
Middle aged
Pays/Région comme sujet:
Asia
Langue:
En
Journal:
PLoS Negl Trop Dis
Sujet du journal:
MEDICINA TROPICAL
Année:
2019
Type de document:
Article
Pays d'affiliation:
Inde