Selection on mutators is not frequency-dependent.
Elife
; 82019 11 07.
Article
de En
| MEDLINE
| ID: mdl-31697233
ABSTRACT
The evolutionary fate of mutator mutations - genetic variants that raise the genome-wide mutation rate - in asexual populations is often described as being frequency (or number) dependent. Mutators can invade a population by hitchhiking with a sweeping beneficial mutation, but motivated by earlier experiments results, it has been repeatedly suggested that mutators must be sufficiently frequent to produce such a driver mutation before non-mutators do. Here, we use stochastic, agent-based simulations to show that neither the strength nor the sign of selection on mutators depend on their initial frequency, and while the overall probability of hitchhiking increases predictably with frequency, the per-capita probability of fixation remains unchanged.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Sélection génétique
/
Évolution moléculaire
/
Taux de mutation
/
Modèles génétiques
Type d'étude:
Prognostic_studies
Langue:
En
Journal:
Elife
Année:
2019
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique