Characterization of DNA methylation-based markers for human body fluid identification in forensics: a critical review.
Int J Legal Med
; 134(1): 1-20, 2020 Jan.
Article
de En
| MEDLINE
| ID: mdl-31713682
ABSTRACT
Body fluid identification in crime scene investigations aids in reconstruction of crime scenes. Several studies have identified and reported differentially methylated sites (DMSs) and regions (DMRs) which differ between forensically relevant tissues (tDMRs) and body fluids. Diverse factors affect methylation patterns such as the environment, diets, lifestyle, disease, ethnicity, genetic variation, amongst others. Thus, it is important to analyse the stability of markers employed for forensic identification. Furthermore, even though epigenetic modifications are described as stable and heritable, epigenetic inheritance of potential markers for body fluid identification needs to be assessed in the long term. Here, we discuss the current status of reported DNA methylation-based markers and their verification studies. Such thorough investigation is crucial to develop a stable panel of DNA methylation-based markers for accurate body fluid identification.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Liquides biologiques
/
ADN
/
Marqueurs génétiques
/
Anthropologie médicolégale
/
Méthylation de l'ADN
/
Sciences légales
Type d'étude:
Diagnostic_studies
/
Prognostic_studies
Limites:
Humans
Langue:
En
Journal:
Int J Legal Med
Sujet du journal:
JURISPRUDENCIA
Année:
2020
Type de document:
Article