Hypercalcemia Heralding Pneumocystis jirovecii Pneumonia in an HIV-Seronegative Patient with Diffuse Cutaneous Systemic Sclerosis.
Mycopathologia
; 184(6): 787-793, 2019 Dec.
Article
de En
| MEDLINE
| ID: mdl-31729682
ABSTRACT
Pneumocystis pneumonia (PCP) is a life-threatening fungal infection occurring in immunocompromised patients such as HIV-positive patients with low CD4 cell count or patients under heavy immunosuppressive therapy. We report the case of a 59-year-old male with severe diffuse cutaneous systemic sclerosis presenting with asthenia, dry cough and worsening shortness of breath for the last 15 days. Biological studies were remarkable for PTH-independent severe hypercalcemia with low 25-hydroxyvitamin D and a paradoxically elevated 1,25-dihydroxyvitamin D. Early bronchoalveolar lavage allowed for PCP diagnosis and targeted treatment. We discuss the underlying physiopathology and difficulties regarding prophylaxis and treatment.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Pneumonie à Pneumocystis
/
Pneumocystis carinii
/
Sclérodermie diffuse
/
Hypercalcémie
Type d'étude:
Diagnostic_studies
Limites:
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Mycopathologia
Année:
2019
Type de document:
Article
Pays d'affiliation:
Belgique