Synthesis of carboxy-polyethylene glycol-amine (CA (PEG)n ) and [1-14 C]-CA (PEG)n via oxa-Michael addition of amino-polyethylene glycols to propiolates vs to acrylates.

Song, Fengbin; Chen, Lu; Lin, Ronghui; Salter, Rhys

Synthesis of carboxy-polyethylene glycol-amine (CA (PEG)_n ) and [1-¹⁴ C]-CA (PEG)_n via oxa-Michael addition of amino-polyethylene glycols to propiolates vs to acrylates.

Song, Fengbin; Chen, Lu; Lin, Ronghui; Salter, Rhys.

Affiliation

Song F; Janssen Research & Development LLC, Janssen Pharmaceutical Companies of Johnson & Johnson, Spring House, Pennsylvania, USA.
Chen L; Janssen Research & Development LLC, Janssen Pharmaceutical Companies of Johnson & Johnson, Spring House, Pennsylvania, USA.
Lin R; Janssen Research & Development LLC, Janssen Pharmaceutical Companies of Johnson & Johnson, Spring House, Pennsylvania, USA.
Salter R; Janssen Research & Development LLC, Janssen Pharmaceutical Companies of Johnson & Johnson, Spring House, Pennsylvania, USA.

J Labelled Comp Radiopharm ; 63(1): 15-24, 2020 01.

Article de En | MEDLINE | ID: mdl-31736118

Sujet(s)
Mots clés

[1-14C]-propiolate; bifunctional crosslinker; carbon-14; carboxy-polyethylene glycol-amine; oxa-Michael addition; radiolabeling

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Polyéthylène glycols / Radiochimie / Acrylates / Radio-isotopes du carbone / Amines Langue: En Journal: J Labelled Comp Radiopharm Année: 2020 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: Royaume-Uni

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